tetracyclines

Recent Rosacea Blog Posts

Yes another one of those `antibiotics + metrogel is all you need’ sort of article. This paper does at least show that low dose doxycycline is gaining weight in the research listings though. Also note that Collagenex naturally has an interest in this sort of published research as they are promoting their periostat and oracea […]

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Incyclinide phase 2 for acne

Written by on September 27, 2005 in tetracyclines with 0 Comments

Formerly known as COL-3, Incyclinide will start a new Phase 2, double-blinded, placebo-controlled trial to find the best treatment dose. This trial will evaluate 300 patients for moderate to severe acne. A recent Phase 2 Clinical Trial showed some promise for inflammatory lesions in rosacea. Incyclinide is a chemically modified tetracycline, modified to retain non-antibiotic […]

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Some more background about subantimicrobial (sometimes referred to as SD – Subantimicrobial Dosage) doxycycline and rosacea. A dosage of around 50mg per day is enough to see a benefit in rosacea symptoms but also low enough to not affect gut flora or cause other antibiotic related side effects. SD doxycycline can also be take safely […]

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A new anti-inflammatory compound has had some Phase 2 Clinical information published. COL-3 is a so called second generation IMPACS (Inhibitors of Multiple Proteases and Cytokines) compound. It is a tetracycline derivate, and is also designated as a Synthetic MMP (Matrix Metalloproteinsase) inhibitor. Guy Webster, MD. PhD the lead investigator for these Phase 2 clinical […]

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