angiogenesis: lymphatic and mast cell involvement

Written by on March 23, 2008 in research foundation, What Causes Rosacea? with 1 Comment

The pathogenesis (how a disease progresses from mild to severe forms) of rosacea is a complicated and poorly understood process. Likewise the growth of new blood vessels, thought to be important in the development of rosacea, is also a complicated and mysterious process. The NRS has updated their blog with an Update on Angiogenesis.

This update refers to 2 recent studies, one linking the lymphatic system with angiogenesis and the second linking the increased presence of mast cells with the later stages of rosacea. Rosacea is certainly a complex disease involving many processes in the inflammatory pathway. It is only through baby steps that we begin to understand more of how this pathway operates.

From:  Update on Angiogenesis

Results of two recent studies provide new understanding of how and when angiogenesis — the formation of new blood vessels — may contribute both to the initial development of rosacea and its persistent presence.

While the development of visible blood vessels, called telangiectasia, has long been recognized in rosacea, evidence of lymphatic vessel growth has not been previously reported, the researchers said. They also noted that study results suggested lymphatic involvement occurs at the beginning of the disease rather than later in its progress. The lymphatic circulatory system consists of vessels that carry a clear liquid that bathes the tissues of the body and may fight infection.

In another study of affected and unaffected skin, Dr. Kyriaki Aroni and colleagues of the University of Athens studied the potential role of angiogenesis and mast cells in rosacea. [2]

“It seems increasingly possible that rosacea pathology is a multifactorial process, which opens up areas of research with regard to potential links between different contributing factors,” the researchers said. Mast cells, connective tissue cells that release chemical substances in response to injury or allergic reaction, are known to augment inflammatory processes and occur in increased numbers in conditions associated with angiogenesis.

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About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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1 Reader Comment

  1. Susan Trulson says:

    I developed Rosecea after recovering from Hodgkin’s Disease, a cancer of the lymphatic system, and I find the possible link to the lymph system very interesting.

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