adding `Licochalcone A’ to finacea and metrogel

`Licochalcone A’ is an extract from Licorice Root (Glycyrrhiza Inflata) and is an ingredient in Eucerin Redness Relief Daily Perfecting Lotion.

Compatibility of skin care formulations containing licochalcone A with commonly prescribed medications for rosacea

Teresa Weber, PhD, Beiersdorf Inc, Norwalk, CT, United States; Ronald Rizer, PhD, Thomas J, Stephens & Associates, Colorado Springs, CO, United States; Anette Buerger, PharmD, Andrea Schoelermann, MD, Beiersdorf AG, Hamburg, Germany

Rosacea can often be managed by pharmacologic treatment, the use of appropriate daily skin care products, and the avoidance of flushing triggers. We examined the stability and compatibility of several commonly prescribed pharmaceutical actives with skin care formulations containing licochalcone A. These formulations were previously tested and shown to be suitable for the daily skin care of patients with erythematotelangiectatic (type 1) rosacea. Chemical stability of the active agents metronidazole and azelaic acid was evaluated by HPLC analytical methods after formulation in an SPF 15 moisturizing cream containing green- and redness concealing pigments, and a night moisturizing cream, both containing licochalcone A. The actives were postadded to the formulations at final concentrations of 0.75% for metronidazole and 15% for azelaic acid, respectively. After 2, 4 and 6 weeks, no loss of actives or changes were observed in samples stored at both room temperature and 378C. Skin compatibility of the drug and skin care formulations was also assessed in subjects with mild to moderate type 1 and 2 rosacea who participated in an in-use test. All subjects applied the drug product alone daily two weeks, followed by the drug and the skin care regimen containing licochalcone A for an additional 2 weeks. Clinical grading of erythema and subjective irritation as well as inflammatory lesions (type 2 rosacea subjects) was made at baseline, and at 2 and 4 weeks. The subjects showed improvements in clinical scores compared to baseline at week 2, and further improvements at week 4. We conclude that the skin care formulations with licochalcone A are compatible with metronidazole and azelaic acid, treatments commonly prescribed for patients with rosacea.

Author disclosure: Nothing disclosed at press time. 100% sponsored by Beiersdorf Inc

Poster Discussion Session P1134, American Academy of Dermatology, 64th Annual Meeting, March 3-7 2006, San Francisco.

Supplement to Journal of The American Academy of Dermatology, March 2006, Volume 54, Number 3.

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About the Author

About the Author:

David Pascoe started the Rosacea Support Group in October 1998.

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1 Reader Comment

  1. Marieke says:

    Hello,
    I don’t read anything about Apple Cidar Vinigar. Untill now ( 2 months)it works very well for me to controll the rosacea.
    I started with using it topically 50 % water 50% ACV. Now I rinse my face with a cotton ball 100% every morning and evening after cleansing it. Then I put a moisterizer over it.
    it surprizes me that nothinmg is said about it.
    Good luck to everyone, Marieke

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