Accutane Gaining More Popularity

Written by on November 1, 2011 in Accutane and Roaccutane, Acne Treatments with 0 Comments

A new paper that highlights the progress made in recent years by researchers who are seeking to prove that accutane is a viable rosacea treatment.

Good News for Accutane Users

This growing body of proof is actually quite important because oral isotretinoin is not officially approved as a treatment for rosacea. Doctors can prescribe accutane off-label for use in rosacea, so more comprehensive trials of accutane can only be a good thing. Further, the growing difficulty in finding a doctor who will actually prescribe accutane means that rosacea sufferers need all the proof that they can get their hands on.

My Take

The paper referenced below was highlighted last year as Doxycycline is as good as Low Dose Accutane (0.3mg/kg/day). It is worth repeating that even though doses of around 20mg a day of accutane compared favourably to 100/50mg of doxycycline, the two drugs have quite different safety profiles. The advice of your doctor is going to be important here.

Rosacea : Systemic therapy with retinoids

Hautarzt. 2011 Oct 22, Thielitz A, Gollnick H, Universitätsklinik für Dermatologie und Venerologie , Otto-von-Guericke Universität, Leipziger Str. 44, 39120, Magdeburg, Deutschland

[Article in German]

Systemic isotretinoin has been known for decades as an effective and safe therapeutic option in the treatment of severe and refractory forms of rosacea. It can also be used in special treatment-resistant forms of rosacea, e. g. granulomatous rosacea, as efficacious second-line therapy.

Previously, the effect of isotretinoin in rosacea has been mainly studied in small cohorts or anecdotal reports.

Recently, a big randomized double-blind dose-response and comparative study revealed that an optimized dosage of 0,3 mg/kg was superior to other dosages and non-inferior to doxycycline as gold standard of systemic rosacea treatment and proved effective and safe in papulopustular and phymatous subtypes.

However, the substance is still not licensed for this indication The efficacy of isotretinoin in rosacea is probably mainly related to anti-inflammatory mechanisms as well as anti-oxidative, anti-angiogenic and antifibrotic properties. The classical antiseborrheic effect of isotretinoin might play a role in special subtypes like the phymatous type or rosacea fulminans.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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