A drug that is said to inhibit nuclear factor kappa beta (NFkB), is to be trialed as a rosacea treatment. The new treatment, code named ACU-D1 will be tested as a treatment primarily for the papules and pustules of rosacea.
Clinical Trial NCT03064438
The study evaluates the safety, efficacy and tolerability of ACCU-D1 when applied twice daily for 12 weeks in adult patients with moderate to severe acne rosacea. Two thirds of participants will receive ACCU-D1 while one third will receive vehicle control.
Primary Outcome Measures: Total Inflammatory Lesion Count [ Time Frame: 12 weeks ] Efficacy as measure by total inflammatory lesion counts
What is ACU-D1?
According to the Accuituis web site;
Our lead discovery compound has activity against the 26S proteasome, one of the beneficial effects of blocking the proteasome is to inhibit the transcription factor nuclear factor kappa beta (NFkB), which is a potent mediator of inflammation.
NFkB has already been shown to be a major, if not the major mediator of skin diseases including Rosacea, Psoriasis, and Acne. In these conditions, inflammation, excess blood vessels, and the enzymes that digest elastic fibers in the skin, are mediated by NFkB. Currently, there are no topical therapies to address proteasomes.
Our compound also has the advantage of extensive toxicology testing in multiple animal species, as well as a safe record of human exposure for over 30 years. ACU-D1 has been formulated into a stable and cosmetically acceptable product which delivers therapeutically relavent concentrations of active to the dermis.
The company further claims that “Our lead product is a transformational first in class treatment for Rosacea.” Time will tell.
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