Abstracts: Elidel, Bacteria & Ocular prevalence

Written by on July 28, 2009 in Ocular Rosacea, research with 0 Comments

The following abstracts don’t deserve a Rosacea News item on their own, but are interesting enough to give a mention here in this Abstract Roundup.

Elidel no better than Metrogel for lumps and bumps of rosacea.

A comparison of metronidazole 1% cream and pimecrolimus 1% cream in the treatment of patients with papulopustular rosacea: a randomized open-label clinical trial. Clin Exp Dermatol. 2009 Jul 6

Patients were randomly assigned treatment with either pimecrolimus 1% cream or metronidazole 1% cream for 12 weeks. Pimecrolimus cream is no more efficacious than metronidazole cream in the treatment of PR.

Another bacterial link found ?

Is rosacea another disorder of gut microbes? Curr Gastroenterol Rep. 2009 Aug;11(4):253-4

This paper sounds like it might be heading in the direction to add to some research that looks at small intestinal bacterial overgrowth as a source of rosacea symptoms. Alas all we can see at the moment is the title. Also note that the author has published several other papers that at least in their title link intestinal disorders with diseases such as fibromyalgia as obesity.

Facial blood vessels correlate to Ocular Rosacea Symptoms

This paper, who’s full text is available via the link, suggests that the presence of facial visible blood (telangiectasia) is more of a clue that ocular rosacea may also be present, compared to other facial symptoms like papules and pustules.

Correlation of the severity of cutaneous rosacea with ocular rosaceaIndian J Dermatol Venereol Leprol 2009;75:405-6.

In our series, ocular involvement did not correlate with the severity of papular, pustular, nodular lesions and flushing but, surprisingly, we found a significant relationship between the severity of telangiectasia and ocular involvement. This finding was not in agreement with the previous studies claiming that the ophthalmologic complications of rosacea are completely independent of the severity of facial rosacea. On the other hand, it seems that the significant relationship between the severity of telangiectasia and eye lesions in our study might be an incidental experience. We agree with the general assumption that skin and eye lesions in rosacea are separate al together.

IAP the link from intestine to Rosacea Skin ?

This paper is proposing that the activity of the enzyme intestinal alkaline phosphatase (IAP) could be the link between an inflammatory response to intestinal bacteria and rosacea skin symptoms.

Intestinal alkaline phosphatase: The molecular link between rosacea and gastrointestinal disease?, Med Hypotheses. 2009 Jun 30 (UMR 168 CNRS/Institut Curie, 11 rue Pierre et Marie Curie, 75005 Paris, France Rosacea Research and Development Institute, Pahala HI 96777, USA)

Rosacea is a common inflammatory condition of the facial skin of unknown etiology, which frequently occurs in combination with gastrointestinal disorders. Many dietary and hormonal factors are known to affect the severity of rosacea symptoms, several of which also modulate the activity of the enzyme intestinal alkaline phosphatase (IAP). The role of IAP in inhibiting an inflammatory response to intestinal bacteria suggests a mechanism by which intestinal pathologies may be linked to the skin inflammation characteristic of rosacea. Analysis of alkaline phosphatase activity is routinely performed on blood samples, and methods to quantify enzyme activity of the intestinal isoform specifically have been described. Correlations between IAP activity and rosacea symptoms in patients and controls can thus be screened by noninvasive and inexpensive means. If IAP activity is found to be low in rosacea patients, acute symptoms could be treated with oral IAP supplementation, and trials of IAP-activating medications currently used in gastrointestinal disease could be initiated in rosacea patients. More importantly, the safe and long-term control of rosacea could be undertaken by patients themselves through dietary modification to naturally increase IAP activity.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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