Itraconazole in the treatment of seborrheic dermatitis: a new treatment modality.
International Journal of Dermatology. 2004 Jan;43(1):63-6.
Baysal V, Yildirim M, Ozcanli C, Ceyhan AM., Department of Dermatology, School of Medicine, University of Suleyman Demirel, Isparta, Turkey.
BACKGROUND: Due to the high rate of recurrence, seborrheic dermatitis (SD) represents a therapeutic problem.
AIM: To evaluate the role of oral itraconazole in the treatment of SD.
PATIENTS AND METHODS: Thirty-two patients with SD were enrolled in the study. All topical and oral treatments were stopped. The patients applied 1% hydrocortisone cream twice daily for 1 month. In addition, they took itraconazole, 200 mg/day, during the first week of the first month and then hydrocortisone cream was stopped and itraconazole (200 mg/day) was given on the first 2 days of the following 11 months. The patients were followed for 2 months without medicine. The severity score was measured at the initial evaluation, and at the first, 12th, and 14th months.
RESULTS: Twenty-eight patients completed the study. There was a statistically significant decrease in the mean severity score at the first, 12th, and 14th months. On the final evaluation at the 12th month, 19 of the 28 patients showed a complete improvement, and three patients showed a slight improvement.
CONCLUSIONS: This study indicates that itraconazole plays an important role in the treatment of SD.
I don’t think many would recommend including the cortisone cream twice daily for 1 month, this may lead to other rosacea related symptoms.
- Rosacea News: seb derm, elidel and protopic : a warning
- Rosacea News: itraconazole and treating seb derm
3 Comments ↓
i`m suffering from sd past 5 years and i used all the products available. please inform me about latest treatments
I’ve had SD for a few years now and have looked everywhere for a simple remedy. Tried all kinds of natural shampoos to no avail . After using Loprox, at $125 a 4 oz bottle, yes it does work great but really!!!??? I saw someone on some website recommed Nizoral AD. This has worked amazingly for me. What an affordable option! Isnt it funny that your medical doctor doesnt suggest this first??
This sounds promising. Am frustrated w/my dermatologist as he seems to offer little to no options. Anyone out there tried UVA or UVB lasers w/any success?
Thanks