I was alerted to the launch of a product called Promiseb by a comment left on the Sebclair for Seborrheic Dermatitis post. Since then the news web sites are also covering the press release. Promiseb (probably pronounced Promi-seb) is launching in the U.S. via Promius Pharma, after being licensed from Sinclair Pharma in 2007.
Promiseb Topical Cream (Sebclair) is a non-steroidal, prescription only cream for the treatment of seborrheic dermatitis. It has demonstrated anti-inflammatory and anti-fungal properties. Sebclair is approved for use in the European Union to treat seborrheic dermatitis. One of Sebclair’s (and now Promiseb’s) claims to fame is that it contains no corticosteroids or immunomodulating agents.
Promiseb is claimed to “Significantly reduced Malassezia yeasts, the organisms that may cause seborrheic dermatitis, by 94%”. These claims are more interesting when you consider the ongoing discussions like Malassezia Globosa causes seborrhea, Pyrithione Zinc is effective, Could M. Globosa Cause Rosacea? and Real cause of seborrhea discovered!.
For a description of the ingredients and suggested method of action see Sebclair for seborrheic dermatitis.
From the press release: Sebclair launched in the US by Dr Reddy’s Laboratories’ subsidiary Promius Pharma, LLC
Jeff Wasserstein, President of Promius Pharma, said “We are very excited about Promiseb Cream because it has the potential to replace both anti-inflammatoryand antifungal treatments in patients with seborrheic dermatitis. In a clinicalstudy Promiseb was shown to have efficacy comparable to desonide cream 0.05% atdays 14 and 28 with fewer relapses.
“Promiseb Cream also has an excellent safety profile with no restrictions onage, duration of use or application on the face.” He continued, “We are very enthusiastic about this product because our clinical research shows thatPromiseb Cream may be used as a first-line treatment for seborrheic flares andfor long-term maintenance”
No Active Ingredients?
A supporting web site for Promiseb is online at http://promiseb.com/ contains a very interesting insight into the Promiseb product itself ;
What is the active ingredient in Promiseb Cream?
Promiseb Cream is a prescription-only, nonsteroidal FDA-cleared medical device and has no active ingredient. However, Promiseb Cream has demonstrated both anti-inflammatory and antifungal properties.
The makers of Promiseb do say that those who are allergic to shea butter or shea nut oil should not use their product though.
It does seem to be an unusual situation; a prescription only medicine that claims to have no active ingredients.
Promiseb Ingredients
Here is the full list of ingredients as detailed in the Promiseb Prescribing Information.
Purified Water, Isohexadecane, Butyrospermum parkii, Pentylene glycol, Ethylhexyl palmitate, Cera alba, PEG-30 Dipolyhydroxystearate, Bisabolol, Polyglyceryl-6 polyricinoleate, Tocopheryl acetate, Hydrogenated castor oil, Acifructol complex, Butylene glycol, Magnesium sulfate, Piroctone olamine, Allantoin, Magnesium stearate, Disodium EDTA, Vitis vinifera, Ascorbyl tetraisopalmitate, Glycyrrhetinic acid, Propyl gallate, and Telmesteine.
User Reviews
Auburn-NH has posted an early review of Promiseb, from using a doctor supplied sample.
Savings Coupon
Promiseb is offering a 50% discount off your co-pay or $40, whichever is less. For more information see Promiseb Savings Coupon.
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21 Comments ↓
Dave,
Based on your experience and knowledge, are any of the ingredients known to aggravate rosacea (recognizing, of course, everybody has their own unique issues).
Larry
Oh if only such a difficult question had a simple answer
None of the ingredients look like obvious no-no for all rosacea sufferers – that is about I can say for now. Hopefully some user reviews will surface over time.
Any Europeans out there already tried it ?
davidp.
Hey,
I have to admit- this product has been pretty effective so far for me. Been using it for about 2 weeks and results have been outstanding so far. Redness around the corner of my nose have been reduced, no itchiness or skin irritation so far..
So Promiseb is the same as Sebclair? Is Sebclair the same as Atopclair? I can only get Atopclair where I live, but it’s hard to find any information differentiating the two.
thanks.
Agree with above reviewer, it is working really well on sides of nose and forehead where I get SB. NOTHING else has worked. I love this stuff so far, its really cleared up my face and I’ve only been using a few times a week – no new flare-ups since i started!!! Thank goodness I was giving up hope.
Auburn-NH is continuing to let us know how her use of Promiseb is going here: My experience with Promiseb
Thanks for your updates Auburn !
my son is 10 and has SD around his nose. he has been
putting Promiseb on for 1 wk now. how soon should we
be seeing some improvement?
Hello TZK,
In one clinical trial comparing Promiseb to Desonide 0.05%, participants saw a benefit after 14 days of use.
all the best,
davidp.
I have been using promiseb for over a week now and see a marked improvement. Moisturizers never worked and seemed to exacerbate the problem. So far, I only have good things to say about promiseb. I wish it wasn’t so expensive. Insane, but what can we do ?
I have been using Promiseb for about a week so far. It seems to be working well around my nose, but every once in a while I get a strong smell that smells like an ashtray. Ever heard of that before? Is there an ingrediant that might cause that?
Hi, I just used promiseb for the very first time and my wife said its made my face a bit more red. Is this normal? Does it irritiate the face, before it starts to work? I know my doctor told me 14 days, but I wasn’t expecting it to get worse..
Thanks to a comment left in the support community area by stingray326 –
The manufacturer of Promiseb is offering co-pay rebates of 50% or $25.00 whichever is less.
https://webrebate.trialcard.com/coupon/Coupon.ashx?t=Promiseb/Promiseb_Web_Coupon.xml&rid=49525325003
davidp.
was looking forward to trying a non-steriod treatment for SD, tried promiseb (atopiclair in Oz) and after four days my skin was worse, was not going to persist for 10 more days. Expensive, ineffective in my case.
PS great site!
I’ve been using Promisehb for 14 days now. For the first 4 days it made my skin much, much worse. It has slowly been drying up the blisters (or whatever you might call the pimple-type irritation) and the itchiness has lessened.
It seems to make the blisters worse at first then better as the day goes on.
I’m disappointed that it hasn’t been more effective, but I’m hopeful.
for the past 2 years I’ve been using Nystatin, which actually kept it at bay for a while – even cleared it up for a couple months. But it came back b/c I stopped applying.
I didn’t know it was a sort of skin condition. I thought I’d just contracted something from someone.
Has anyone else has this worse-before-better reaction to Promisehb?
Just got prescribed Promiseb today for my rosacea and SB. Does it reduce redness as well as getting rid of the dry skin? Ive tried Elidel which contained steroids and it made my skin less flaky but far more red. Almost as if my skin was glowing. If someone can give me their experience with Promiseb it would be greatly appreciated. Thanks
Comment via email from Anthony:
“I had a rash develop over my face to a point where at least 80% of my face was red, inflamed and itchy and flaky, I thought it was SD but the doctor said it was rosacea and prescribed steroid cream. I didn’t want to use a steroid as I’d heard it perhaps caused the rosacea in the first place. I heard about Mario Bedescu on rosacea-support.org, ordered some from the US, rash gone, flaking gone, no sign of previous symptoms! The promiseb didn’t work on my face, it did work on a small patch on my chest. I don’t know whats going on with these rashes but I have them under control after a decade of insecurity and discomfort. Try Mario. Hope this helps”
I just got this from my derm but he did not say whether or not it should still be used with rosacea topicals. Does this also do the job of metrocream?
Hi Heather,
I think the best answer to that question comes from your derm as I haven’t seen any evidence of how well Promiseb can replace metrocream. If you have seborrheic dermatitis as well as rosacea then using it together is probably beneficial.
I was slightly surprised to see the makers of Promiseb claiming that their product contains no active ingredients – despite it being a prescription only medication. Weird.
all the best,
davidp.
Does promiseb topical cream work for dark spots?
It looks like Promiseb has taken the color out of our pillowcases. Has anybody else experienced this?