This recently published paper investigates the effectiveness of a `novel steroid-free cream containing multiple active ingredients’, called Sebclair to treat facial seborrheic dermatitis.
This product sounds quite interesting for rosacea and rosacea/SD sufferers. Little information about Sebclair is currently available on the internet.
Sebclair (MAS064D) is approved for use in the European Union to treat seborrheic dermatitis. One of Sebclair’s claim to fame is that it contains no corticosteroids or immunomodulating agents. The paper’s authors admit that it is difficult to know which compound is responsible for Sebclair’s success as a treatment.
The authors state “We believe that the major activity is probably due to the synergistic effect of both piroctone olamine, for its antimycotic action, and glycyrrhetinic acid, for its anti-inflammatory action.”
Sebclair Ingredients
| Ingredient | Concentration | Role |
| Isohexadecane | 8% | Emollient |
| Shea butter | 6% | Emollient |
| Bisabolol | 1.2% | Anti-inflammatory |
| Piroctone olamine | 1% | Antimycotic |
| Alglycera | 1% | Anti-inflammatory and keratolytic |
| Vitamin E | 1% | Anti-inflammatory and antioxidant |
| Allantoin | 0.35% | Keratolytic |
| V. vinifera | 0.1% | Anti-oxidant |
| Telmesteine | 0.01% | Anti-inflammatory and antioxidant |
The following descriptions of each ingredient is supplied in the full text of the paper.
Alglycera is a compound combining the anti-inflammatory properties of glycyrrhetinic acid and the keratolytic properties of allantoin.
Glycyrrhetinic acid, extracted from the licorice root, exhibits anti-inflammatory properties in different organs in several animal models,
with a potency similar to that of indomethacine. Its chemical structure is similar to that of cortisone and has been shown to potentiate the action of hydrocortisone
Piroctone olamine is an antimycotic effective against Malassezia spp.
The standardized extract of V. vinifera (grapevine) in Sebclair contains 40% of epigallocatechin gallate, a proanthocyanidine that prevents oxidative damage to the endothelium, with maintenance of optimal blood supply. It works as an antioxidant synergistically with telmesteine and Vitamin E.
Shea butter, from Butyrospermum parkii, is composed of tryglycerides and fatty acids, including linoleic acid, rich in phytosterols and tocopherols. The action of shea butter is enhanced by isohexedecane, another emollient present in the formulation.
If you live in the EU and suffer from SD, please do let us know how you like Sebclair, but leaving a comment below.
Treatment of mild to moderate seborrhoeic dermatitis with MAS064D (Sebclair), a novel topical medical device: results of a pilot, randomized, double-blind, controlled trial, J Eur Acad Dermatol Venereol. 2008 Mar;22(3):290-6. S Veraldi, A Menter, M Innocenti, Institute of Dermatological Sciences, University of Milan, IRCCS Foundation, Policlinico, Mangiagalli and Regina Elena Hospital, Milan, Italy; Baylor University Medical Centre, Dallas, TX, USA, European Institute of Dermatology, Milan, Italy
Aim: MAS064D (Sebclair) is a novel steroid-free cream containing multiple active ingredients. Objective of this pilot study was to evaluate the efficacy and safety of MAS064D in the treatment of mild to moderate SD of the face.
Methods: Patients (n= 60) with SD were randomized to receive MAS064D (n= 40) or a matching vehicle (n = 20). The primary study endpoint was investigators’ global assessment (IGA) score at day 28, compared with baseline. Secondary endpoints included: IGA score at day 14; investigators’ assessment of erythema and scaling; patients’ assessment of burning/stinging, pruritus and global response to MAS064D; resort to rescue medication; quality of life.
Results: Use of MAS064D for 4 weeks was associated with a higher percentage of success in the MAS064D group than in the vehicle group (~68% vs 11%, P < 0.0001). The effects of MAS064D were significantly better than those of vehicle for investigator-assessed erythema and scaling, and patients’ assessed pruritus and global response to MAS064D (P ≤ 0.01). No patient in the MAS064D
group required rescue medication, compared with two patients in the vehicle group. Four patients (two each in the MAS064D and vehicle groups) reported a total of six non-serious adverse events.
Conclusions: MAS064D appears to be an effective and well tolerated cream for the treatment of mild to moderate SD of the face. Further clinical evaluation of MAS064D in SD is warranted.
Update: Sebclair has launched as Promiseb Cream in the United States.
Sinclair Pharma: Sebclair
20 comments ↓
Is this available yet in the US? I also travel to the UK and Europe from time to time, and it seems to indicate on their website that this could be available both over the counter and by prescription. Either way as I’m in London today I will try to see if I can find some as this would be very helpful for me.
I don’t believe that it is available in the US yet, but would love to hear from someone if they do find it.
I would love to try it. I ask my family to look for it in Spain and they did not find it.
I would like to try it. It’s not available at the pharmacy where I buy my medicine in South Africa.
Unfortunately this product is still very new. Would love to hear from people that have been able to find it and even better have tried it !
would love to know where to buy this in the uk,as my skin is so bad on my face please help.
elidel not workin for me i want to try sebclair is it available in uk plz… anyone
SebClair is sold in US by Dr Reddy (http://www.drreddys.com)
for Europe here is an Italian website seller
http://www.farmaciamontera.it/product_info.php?products_id=912465919
for Uk concact sinclair company
http://www.sinclair.com/
Please advise when Sebclair will be available for sale as a prescription product in the United States. Thank you.
Tom
Apparently Dr. Reddy’s will be the exclusive marketer of Sebclair in the US. It was also announced in Sep 2007 that Dr. Reddy’s would market Sebclair under a new brand name. It was expected to be launched within a year.
Sinclair Pharma plc announces Dr Reddy’s Laboratories, Inc. as Sebclair marketing partner in US
If I find out anything more about this product I will post it here.
davidp.
It looks like Australians can easily get this prepartion via mail and pay via paypal.
It appears to be called Atopiclair and is available from
http://www.atopiclair.com.au/ It is listed as Atopiclair Cream 40ml and is $49 including postage to anywhere in Australia.
The web site claims a “new, non-steroidal cream that is designed to relieve the symptoms and signs of eczema (atopic dermatitis) and allergic dermatitis (contact dermatitis).”
Going by the papers they cite on that page and the paper above both quoting MAS063DP (Atopiclair[TM]), and the fact that Otco Global is listed as the Australian distributor – I’d say that this is Sebclair.
davidp.
So Atopiclair is the same as Sebclair then?
Well based on my reading, yes it is the same thing. I haven’t found an official statement saying that it is, but according to my reasons above I’m pretty confident.
If someone finds something more definitive than my detective work above, please do let us know.
‘So Atopiclair is the same as Sebclair then?’
I don’t think it is, Atopiclair is for those with Atopic Dermatitis and Sebclair is for those with Seborrheic Dermatitis.
The active ingredient is marketed and targeted at both of these conditions.
I would like to try this product ,how can i get it in israel ?
I have seborrheic dermatitis and was just given a brand new cream called: Promiseb put out by: Promius Pharma.
It contains the exact active ingredients as your website de-
scribes in Sebclair! I have no idea how much it is, but I’m sure it’s exspensive. It comes in 30g tubes. (I was given samples) I will let you know how it does.
Thanks Margaux, I felt sure it would surface soon. Please do let us know how you get on.
It looks like the Promiseb Prescribing Information is also available online on the Promiseb web site.
I want to pronounce it Promise-b, but I guess because of “seb” in the name is would be said Promi-Seb …
davidp.
I was given some Sebclair and almost as soon as I used it the redness and itching died down, and although i still have some of the symptons, my skin is in the best condition it has been in a long time. Unfortunately I don’t know where you would be able to get this yourselves but when you do find it, try it!
So Sebclair = Atopiclair = Promiseb?
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