Rosasol is a little known combination sunscreen and metronidzaole formulation. It is only available on prescription in Canada. According to the Stiefel Laboratories web site, “Regulations in Canada prohibit pharmaceutical manufacturers from providing prescription-product-related information directly to consumers“. This may explain why little information about Rosasol is available on the internet.
Randomized Placebo-controlled Trial of Metronidazole 1% Cream with Sunscreen SPF 15 in Treatment of Rosacea
J.K.L. Tan, C. Girard, A. Krol, H.E. Murray, K.A. Papp, Y. Poulin, D.A. Chin, D. Jeandupeux.
Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology, Issue: Volume 6, Number 6, December 2002, Pages: 529 - 534.
Background: Rosacea is a photoaggravated dermatosis responsive to treatment with topical and oral antibiotics. A formulation combining metronidazole 1% cream with sunscreen SPF 15 was developed for the treatment of rosacea. Objective: The objective of this study was to determine the safety and efficacy of a formulation combining metronidazole 1% cream with sunscreen SPF 15 in the treatment of moderate to severe rosacea.
Methods: One hundred and twenty patients with moderate to severe rosacea were enrolled for a randomized, placebo-controlled (vehicle containing sunscreen with SPF 15), double-blind study. Study cream was applied twice daily to the entire face over a 12-week period.
Results: Treatment with metronidazole 1% cream with sunscreen SPF 15 resulted in significant improvement (p <0.05) in inflammatory lesion count, erythema and telangiectasiae scores, and investigator and patient global assessment scores compared with baseline and placebo. Adverse reactions related to study medication were typically mild, occurred at the site of application, and were reversible. There was no difference between the safety profiles of metronidazole 1% cream with sunscreen SPF 15 and placebo.
Conclusions: The combined topical formulation of metronidazole 1% cream with sunscreen SPF 15 was an effective, well-tolerated topical agent for the treatment of moderate to severe rosacea.
Also from JK Tan is a 2001 Letter:
Skin Therapy Letters. 2001 May;6(8):1-2.
A new formulation containing sunscreen (SPF 15) and 1% metronidazole (ROSASOL Cream) in the treatment of rosacea.
Tan JK, Acne Research and Treatment Center, Windsor, Ontario, Canada.
ROSASOL Cream is a novel topical formulation of 1% metronidazole in a vehicle containing sunscreens (SPF 15). This product has demonstrated efficacy in the treatment of inflammatory lesions, erythema, and telangiectasiae associated with rosacea.
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1 comment so far ↓
I use this cream and I must say that it works well, but at first it dried my face out. I would recommend it to someone with this disease.
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