Comments on: Q&A with Clinuvel on Afamelanotide and Melanotan http://rosacea-support.org/qa-with-clinuvel-on-afamelanotide-and-melanotan.html Where the rosacea community meets to support each other Wed, 23 May 2012 15:17:41 +0000 hourly 1 http://wordpress.org/?v=3.3.2 By: LPC http://rosacea-support.org/qa-with-clinuvel-on-afamelanotide-and-melanotan.html/comment-page-1#comment-33119 LPC Sat, 27 Feb 2010 02:49:39 +0000 http://rosacea-support.org/qa-with-clinuvel-on-afamelanotide-and-melanotan.html#comment-33119 In theory, melanocyte stimulating hormones and variants could have positive impact on virtually all inflammation related diseases (usually autoimmune) ranging from osteo arthritis, crohns disease, inflammatory bowel disease, rosacea. Promise has been shown in mitigating congestive heart failure, metabolic syndrome and more. Although current methods of use range from subcutaneous injection & dissolvable solid implants to nasal sprays. Most interesting has been some research at gene transplantation (expression?) which appears to permanently bond that MSH gene to you. In theory, melanocyte stimulating hormones and variants could have positive impact on virtually all inflammation related diseases (usually autoimmune) ranging from osteo arthritis, crohns disease, inflammatory bowel disease, rosacea. Promise has been shown in mitigating congestive heart failure, metabolic syndrome and more.

Although current methods of use range from subcutaneous injection & dissolvable solid implants to nasal sprays. Most interesting has been some research at gene transplantation (expression?) which appears to permanently bond that MSH gene to you.

]]> By: LPC http://rosacea-support.org/qa-with-clinuvel-on-afamelanotide-and-melanotan.html/comment-page-1#comment-33118 LPC Sat, 27 Feb 2010 02:42:29 +0000 http://rosacea-support.org/qa-with-clinuvel-on-afamelanotide-and-melanotan.html#comment-33118 Palatin is developing a variant of Melanotan II called Bremelanotide. Again, a rose is a rose. alpha-melanocyte stimulating hormone has shown very promising positive results in reducing systemic inflammation but the approach is to develop and approve the use for one disease or organ at a time. Currently renal failure is the flavor of the month. Check at NIH and Medline to see progress. http://clinicaltrials.gov/ct2/show/NCT00004496?term=melanocyte&rank=5 Palatin is developing a variant of Melanotan II called Bremelanotide. Again, a rose is a rose.

alpha-melanocyte stimulating hormone has shown very promising positive results in reducing systemic inflammation but the approach is to develop and approve the use for one disease or organ at a time. Currently renal failure is the flavor of the month. Check at NIH and Medline to see progress.

http://clinicaltrials.gov/ct2/show/NCT00004496?term=melanocyte&rank=5

]]> By: Kyle http://rosacea-support.org/qa-with-clinuvel-on-afamelanotide-and-melanotan.html/comment-page-1#comment-33110 Kyle Fri, 26 Feb 2010 18:24:44 +0000 http://rosacea-support.org/qa-with-clinuvel-on-afamelanotide-and-melanotan.html#comment-33110 Wolgen is against off-label usage. That leaves a few thousand people he would prescribe this to. Meanwhile millions of fair-skin people will just have to do without it unless they can somehow pay through the nose or find a doc to prescribe it off-label. He also failed to mention how far the company has fallen behind on their prior announced plans of when the drug would be commercialized. A review of official announcements dating back to his 4 year tenure will uncover all that. If they are so against people using Melanotan, maybe they can find a reasonable way for their drug to be accessible to others who need the increased melanin protection. But of course, that would be operating under common sense. Wolgen is against off-label usage. That leaves a few thousand people he would prescribe this to.

Meanwhile millions of fair-skin people will just have to do without it unless they can somehow pay through the nose or find a doc to prescribe it off-label.

He also failed to mention how far the company has fallen behind on their prior announced plans of when the drug would be commercialized. A review of official announcements dating back to his 4 year tenure will uncover all that.

If they are so against people using Melanotan, maybe they can find a reasonable way for their drug to be accessible to others who need the increased melanin protection.

But of course, that would be operating under common sense.

]]> By: Jonathan Peters http://rosacea-support.org/qa-with-clinuvel-on-afamelanotide-and-melanotan.html/comment-page-1#comment-33104 Jonathan Peters Fri, 26 Feb 2010 12:08:53 +0000 http://rosacea-support.org/qa-with-clinuvel-on-afamelanotide-and-melanotan.html#comment-33104 Philippe Wolgen is a bit sparing on the details and essentially deceptive in what he says relative to the history of this drug. Epitan was the company name that Clinuvel went by until 2006. Clinuvel (as Epitan) used the word 'melanotan' in their development of the now generic drug afamelanotide until 2005 (see: http://www.google.com/search?rls=en-us&q=site:clinuvel.com+%22melanotan+implant%22&ie=UTF-8&oe=UTF-8 ). The peptide sequence for afamelanotide is the same peptide sequence for melanotan-1. A rose by any other name is still a rose. There is nothing illegal in laboratories producing and selling melanotan-1 as a molecular substance. The patent for the melanotan-1 molecule expired in 2006. The primary illegal aspect of companies selling melanotan-1 is if they sell it specifically for human usage. For Clinuvel the only thing proprietary about the drug at this point lies in administration methods. Sincerely, Jonathan Peters of Hinxworth, England Philippe Wolgen is a bit sparing on the details and essentially deceptive in what he says relative to the history of this drug. Epitan was the company name that Clinuvel went by until 2006. Clinuvel (as Epitan) used the word ‘melanotan’ in their development of the now generic drug afamelanotide until 2005 (see: http://www.google.com/search?rls=en-us&q=site:clinuvel.com+%22melanotan+implant%22&ie=UTF-8&oe=UTF-8 ). The peptide sequence for afamelanotide is the same peptide sequence for melanotan-1. A rose by any other name is still a rose.
There is nothing illegal in laboratories producing and selling melanotan-1 as a molecular substance. The patent for the melanotan-1 molecule expired in 2006. The primary illegal aspect of companies selling melanotan-1 is if they sell it specifically for human usage.
For Clinuvel the only thing proprietary about the drug at this point lies in administration methods.

Sincerely,
Jonathan Peters of Hinxworth, England

]]>