In a followup article on François Fournier, the head of Galderma USA, the Dallas Forth Worth Daily raises the topic of rebound flushing from Mirvaso.
Whilst only quoting one online forum posting, the author Bradford Pearson highlights what he calls the mixed response to the newly released topical Mirvaso.
Indeed it is a question that needs some investigation – does it indeed cause rebound redness and if so, why does Mirvaso appear to cause worse redness than before the user starting using it.
“I think it’s important for me to reinforce that 16 million people have rosacea in the U.S.” he told D Healthcare Daily earlier this month. “It’s an inflammatory and vascular disease. It’s a chronic disease. And most of them have erythema and this product will bring a solution. There is a big market, they have a lot of patients suffering. Before this product, there was no product working.”
But since the product’s release, results have been mixed. Online rosacea message boards have roundly attacked the product, saying that the rebound flushing caused by the drug was worse than the initial redness itself.
“I’m nine days since my last Mirvosa application, and I am still feeling the bad effects from use,” wrote one user. “I used a very small amount for three days, on my nose mostly, spreading it out to my cheeks, but the rebound is affecting my whole face, including my chin, which never flushes. I’m starting to believe that the rebound is over, and that this is going to be a permanent deterioration of my condition due to the inflammation I experienced after I stopped use.”
Sansrosa Research Looked Good
The clinical trial results (well at least those which were easily available to the public) looked quite positive. There was no appearance of problems with rebound redness or problems if you stopped and starting using the gel.
This is further reinforced from a quote on November 1 from Dr. Rosso:
Addressing facial erythema, DermatologyTimes, Nov 1, 2013.
By: Ilya Petrou, M.D.
Most recently FDA-approved for treatment of persistent nontransient facial erythema of rosacea in patients age 18 and older, brimonindine tartrate 0.5 percent gel (brimonidine 0.33 percent, Mirvaso, Galderma) applied once daily has been shown to reduce diffuse facial erythema of rosacea with a usual onset within 30 minutes and with peak activity over approximately eight to 10 hours.
According to Dr. Del Rosso, the safety profile appears to be favorable, rebound has not emerged as a major problem with this agent, and tachyphylaxis has not been observed.
So Does Mirvaso work or not?
Only time will reveal whether the initial negative reaction online to Mirvaso bears out in the larger populatio as Mirvaso’s usage becomes more widespread.
Rosacea can be a tricky disease to treat, especially when blushing and flushing and hyper reactive skin may be present also.
Daily Mail Mention
A Daily Mail article also has a reference to the negative reports of Mirvaso that are emerging online. This cannot have escaped the notice of Galderma.
By JO WATERS
And there are potential side-effects – one study of 276 people found 4 per cent reported flushing, redness, a skin-burning sensation and allergic contact dermatitis.
Some patients have complained in online forums that the ‘rebound’ flushing caused when the drug wore off was worse than the initial redness caused by rosacea.
Dr Mark Jackson, chief investigator on the U.S. Mirvaso trials, said it was often difficult for patients to remember what their skin was like before treatment unless they photographed themselves.
You can immediately tell the quality of any article reporting on rosacea if they use the word spider when referring to Demodex Mites then you shouldn’t trust much else that they write.
So the quality of the article is low, but it is worth noting that a good objective measure of redness at baseline and during and after using Mirvaso is a good place to start in deciding if it works for you.
- Sansrosa not Susceptible to Tolerance or Rebound
- Mirvaso to be a $100 million drug for Galderma
- Mirvaso User Reviews
- Will I have a Bad Reaction to Mirvaso?
- Mirvaso Before and After Pictures
- Mirvaso Rebound Flushing – What About it?