The following recently published article confirms that melanotan is showing promise as a sun protection for people with fair skin who normally burn in direct sunlight.
Melanotan, [Nle4, D-Phe7]-a-MSH, significantly increased pigmentation and decreased UV damage in fair-skinned white volunteers, Ross Barnetson, MD, Sydney University, Sydney, NSW, Australia
Epidermal melanin can reduce some of the effects of UVR, which is the major cause of skin cancer. To examine whether induced melanin can provide protection from sunburn injury, we recruited 79 subjects into a clinical trial with the potent synthetic melanotropin Melanotan, delivered by subcutaneous injection into the abdomen at 0.16 mg/kg for three 10-day cycles over 3 months. Sixty-five subjects completed the trial and, compared with placebo, the skin melanin density, measured by reflectance spectroscopy, increased significantly in all Melanotan-treated subjects. The highest increases were seen in those volunteers with the lowest baseline skin melanin levels. In subjects with a skin type associated with a low MED at baseline, melanin increased by an average of 41% (from 2.55 to 3.59, P<.0001 vs placebo) over 8 separate skin sites, compared with only 12% (from 4.18 to 4.70, P <.0001 vs placebo) in subjects with a high MED skin type. Epidermal sunburned (apoptotic) cells resulting from exposure to 3 X an individual’s MED exposure of solar-simulated UVR were reduced by more than 50% after Melanotan treatment in the volunteers with low baseline MED. DNA damage, in the form of thymine dimer formation, was also shown to be reduced by 59% (P < .0033) in the basal layer of the epidermis of this group of subjects. This study has shown for the first time the potential ability of a synthetic hormone that augments melanin production to provide photoprotection to people who normally burn in direct sunlight.
Author disclosure: Consultant to Epitan Ltd. 100% sponsored by Epitan Ltd, Melbourne, Australia.
Poster Discussion Session P2621, American Academy of Dermatology, 64th Annual Meeting, March 3-7 2006, San Francisco.
Supplement to Journal of The American Academy of Dermatology, March 2006, Volume 54, Number 3. JAAD Poster Abstracts Online (29Mb)
4 comments ↓
hi i want to buy this epitan where can i purchase it?
Unfortunately as these products are still in development, it is not so easy to get hold of them. They are aren’t approved for use by the FDA so you need to get hold of it through other means. I’d caution that there all the side effects and doses etc. aren’t nailed down so it is a risk you would need to be willing to take.
davidp.
how do i get it through other means???
I would like to find out how and where to buy melanotan and the prices.
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