What did the doctor prescribe? Does the bottle say to take them both at once, or split them up? When I was taking my generic version of Oracea, I took the one pill (50 mg doxycycline) in the morning. Originally, my derm had me on 100 mg doxy daily for two weeks, and he had me split that dosage up, but I must admit it was harder to remember to do so! Another member took two Oracea tablets at the same time, in the morning, under her doctor's orders.
I'm trying to find anything on the board to see if someone else also took Periostat and what they did. Hmmm, here's a thread, but it might just confuse you.
http://rosacea-support.org/community/viewtopic.php?f=13&t=186&p=3295&hilit=periostat#p3295Just check with your derm and see what he says, and why he recommends doing it that particular way. Remember to take it one hour before eating, or two hours after eating (or with a cracker if you get stomach upset). I took mine with food, and I wasn't supposed to (for some reason, my derm said it was okay!); that's probably why it didn't work.