Comments on: cathelicidins regulated by Vitamin D3 http://rosacea-support.org/cathelicidins-regulated-by-vitamin-d3.html Where the rosacea community meets to support each other Thu, 18 Mar 2010 07:03:43 +0800 http://wordpress.org/?v=2.9.2 hourly 1 By: Todd http://rosacea-support.org/cathelicidins-regulated-by-vitamin-d3.html/comment-page-1#comment-26124 Todd Mon, 12 Jan 2009 20:45:15 +0000 http://rosacea-support.org/cathelicidins-regulated-by-vitamin-d3.html#comment-26124 The recent papers and discussion about D3 relative to rosacea and skin disorders is interesting to me. About 4 months ago I started a daily regimine of 2000-4000 IU dose Vitamin D3 orally as a wintertime immune boosting effort since I live in a northern climate were defficiencies would be the case in winter when no significant daily sunlight exposure would be adequate to stimulate my body's natural production of the vitamin. After a couple months I began to notice that despite not using any of my prescribed Rosacea treatments, my rosacea symptoms had nearly completely subsided. I kept wondering in the back of my mind if the D3 could possibly be having any impact. I know this is only one observation and it is not a controlled scientific evaluation that one could draw solid conclusions from, but these results have me very interested and wondering. I get what the previous post is saying about how D3 could actually increase or worsen rosacea symptoms, but I can say that in my case, this has not been true. -- that being said, I know it doesnt mean that others skin wouldnt react to it differently. Just wanted to share my observation. The recent papers and discussion about D3 relative to rosacea and skin disorders is interesting to me. About 4 months ago I started a daily regimine of 2000-4000 IU dose Vitamin D3 orally as a wintertime immune boosting effort since I live in a northern climate were defficiencies would be the case in winter when no significant daily sunlight exposure would be adequate to stimulate my body’s natural production of the vitamin. After a couple months I began to notice that despite not using any of my prescribed Rosacea treatments, my rosacea symptoms had nearly completely subsided. I kept wondering in the back of my mind if the D3 could possibly be having any impact. I know this is only one observation and it is not a controlled scientific evaluation that one could draw solid conclusions from, but these results have me very interested and wondering. I get what the previous post is saying about how D3 could actually increase or worsen rosacea symptoms, but I can say that in my case, this has not been true. — that being said, I know it doesnt mean that others skin wouldnt react to it differently. Just wanted to share my observation.

]]> By: Alex http://rosacea-support.org/cathelicidins-regulated-by-vitamin-d3.html/comment-page-1#comment-18238 Alex Sat, 24 May 2008 11:17:55 +0000 http://rosacea-support.org/cathelicidins-regulated-by-vitamin-d3.html#comment-18238 There is a more comprehensive abstract of the last paper you mentioned there: http://www.nature.com/jid/journal/v128/n4/pdf/jid200835a.pdf It is important to emphasize that this research does not imply that increasing Vitamin D3 consumption would improve rosacea. Vitamin D3 is likely to increase the production of cathelicidins, which has been demonstrated to be a major inflammation factor for rosacea sufferers. As Vitamin D3 production is induced by sun exposure, this paper mentions that the well-known negative effect of sun on rosaceans skin could be mediated by vitamin D3. A lot of evidence therefore suggest Vitamin D3 to be an enemy for the rosacea sufferer, while it could help other inflammatory skin disease. This paradox could be explained by rosacea being induced by a defective immune anti-microbial response, as envisaged by previous research covered here. There is a more comprehensive abstract of the last paper you mentioned there: http://www.nature.com/jid/journal/v128/n4/pdf/jid200835a.pdf

It is important to emphasize that this research does not imply that increasing Vitamin D3 consumption would improve rosacea.
Vitamin D3 is likely to increase the production of cathelicidins, which has been demonstrated to be a major inflammation factor for rosacea sufferers. As Vitamin D3 production is induced by sun exposure, this paper mentions that the well-known negative effect of sun on rosaceans skin could be mediated by vitamin D3.

A lot of evidence therefore suggest Vitamin D3 to be an enemy for the rosacea sufferer, while it could help other inflammatory skin disease.

This paradox could be explained by rosacea being induced by a defective immune anti-microbial response, as envisaged by previous research covered here.

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