I have forwarded you contact details for Seth.

I had read the paper, but didn’t dwell on “Whole gut transit time (WGTT) was
measured by the passage of ingested charcoal capsules”.

An interesting thought that this could be responsible for some of the benefits that were observed.

Good Luck,
davidp.

If:

• Rosacea is a hypersensitivity reaction to a pathogen (several are implicated)

And:

• Endotoxins may be the cause of the hypersensitivity

Then:

I posit that the initial very positive response to the intervention perhaps wasn’t due to the bran at all, but could have been due to the activated charcoal used to determine gut transit time, which may have absorbed some of the endotoxins.

Supporting evidence:

1: Novokreshchenov LB, Dolgushin II, Andrushenko ON, Kuchenkova MA, Chukichev AV,
Shish VF, Imamov MZ. [Enterosorption as a method of total detoxication and
nonspecific immune correction in acute surgical infection (a
clinical-experimental study)]. Pediatriia. 1989;(12):62-6. Russian. PubMed PMID:
2628913.

2: Gardiner KR, Anderson NH, McCaigue MD, Erwin PJ, Halliday MI, Rowlands BJ.
Adsorbents as antiendotoxin agents in experimental colitis. Gut. 1993
Jan;34(1):51-5. PubMed PMID: 8432452; PubMed Central PMCID: PMC1374100.

3: Ditter B, Urbaschek R, Urbaschek B. Ability of various adsorbents to bind
endotoxins in vitro and to prevent orally induced endotoxemia in mice.
Gastroenterology. 1983 Jun;84(6):1547-52. PubMed PMID: 6341160.

4: Vega-Franco L, Velasco-Sánchez F, Pérez JE. [Effect of the administration of
adsorbents on the bacterial flora of the rat intestine]. Bol Med Hosp Infant Mex.
1982 Apr;39(4):259-63. Spanish. PubMed PMID: 7093032.

5: Abbès S, Ben Salah-Abbès J, Abdel-Wahhab MA, Ouslati R. Immunotoxicological
and biochemical effects of aflatoxins in rats prevented by Tunisian
montmorillonite with reference to HSCAS. Immunopharmacol Immunotoxicol. 2010
Sep;32(3):514-22. PubMed PMID: 20088648.

6: Jung BG, Toan NT, Cho SJ, Ko JH, Jung YK, Lee BJ. Dietary aluminosilicate
supplement enhances immune activity in mice and reinforces clearance of porcine
circovirus type 2 in experimentally infected pigs. Vet Microbiol. 2010 Jul
14;143(2-4):117-25. Epub 2009 Dec 22. PubMed PMID: 20022715.

7: Thieu NQ, Ogle B, Pettersson H. Efficacy of bentonite clay in ameliorating
aflatoxicosis in piglets fed aflatoxin contaminated diets. Trop Anim Health Prod.
2008 Dec;40(8):649-56. Epub 2008 Mar 5. PubMed PMID: 18975130.

8: Wang JS, Luo H, Billam M, Wang Z, Guan H, Tang L, Goldston T, Afriyie-Gyawu E,
Lovett C, Griswold J, Brattin B, Taylor RJ, Huebner HJ, Phillips TD. Short-term
safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans.
Food Addit Contam. 2005 Mar;22(3):270-9. PubMed PMID: 16019795.

9: Afriyie-Gyawu E, Mackie J, Dash B, Wiles M, Taylor J, Huebner H, Tang L, Guan
H, Wang JS, Phillips T. Chronic toxicological evaluation of dietary NovaSil clay
in Sprague-Dawley rats. Food Addit Contam. 2005 Mar;22(3):259-69. PubMed PMID:
16019794.

10: Ducrotte P, Dapoigny M, Bonaz B, Siproudhis L. Symptomatic efficacy of
beidellitic montmorillonite in irritable bowel syndrome: a randomized, controlled
trial. Aliment Pharmacol Ther. 2005 Feb 15;21(4):435-44. PubMed PMID: 15709995.

Donna L. Beales, MLIS

Then I read many more papers that, quite frankly, were above my chemistry level of comprehension . . But I was certainly able to master the conclusion !

I guess I had an “AHA” moment. What I have been trying to do is fix the result of inflamation & bacteria that has its origin somewhere else. The mess I have with my skin now is the result of something much bigger. . . located somewhere else (gut) !

There is quite a lot in current publication, but I found the easiest way to find it was through the biology door.

Barbara