July 4th, 2007, by Digital Davo | clinical trials, doxycycline, metrogel, oracea
A clinical trial, sponsored by CollaGenex, is recruiting patients to see how Oracea compares to doxycycline (100mg once a day) when combined with metrogel 1%. We can see from a Collagenex annual report that COL-101 was the name for Periostat MR, which then became Oracea. Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens Purpose: To compare the safety and efficacy of two treatment …
June 18th, 2007, by Digital Davo | metrogel
Two recently published papers look at the processes involved when you apply metrogel topically. The first abstract just tells us that they undertook some new ways of measuring metronidazole absorption, but doesn’t reveal their results. The second abstract suggests that a cream based metronidazole formulation (presumably metrocream, but could also include Noritate) had the greatest absorption when tested with human skin. They suggest that future …
March 20th, 2007, by Digital Davo | metrogel, rosacea cause
I have mentioned a few times in the past that the way that metrogel helps rosacea is unknown. This statement deserves some clarification. Actually the way that metronidazole works is well known. How the effect of metrogel leads to a benefit in rosacea, well, that is something worth exploring some more later on. You may wonder why there is so much emphasis on the metronidazole based products …
May 15th, 2006, by Digital Davo | metrogel
Despite quite a lot of activity in the marketing and development of the metronidazole treatments (lotion, cream, gel, generic equivalents, metrogel 1%, once per day, twice per day) this research suggests that the formulation and treatment frequency make little difference to the treatment outcome. So if you can tolerate one of the available formulations, there is likely marginal benefit from changing to another.
Metronidazole in the …
March 8th, 2006, by Digital Davo | IPL, metrogel
Intermittent pulsed light therapy in combination with metronidazole 1% gel for the treatment of patients with mild to moderate rosacea: A pilot studyMichael Gold, MD, Gold Skin Care Center, Tennessee Clinical Research Center, Nashville, TN, United StatesRosacea is a common dermatologic disorder characterized by the presence of facial erythema, visible blood vessels, and acneiform papules and pustules. With the face being …
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