July 4th, 2007, by David Pascoe | clinical trials, doxycycline, metrogel, oracea
A clinical trial, sponsored by CollaGenex, is recruiting patients to see how Oracea compares to doxycycline (100mg once a day) when combined with metrogel 1%. We can see from a Collagenex annual report that COL-101 was the name for Periostat MR, which then became Oracea. Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens Purpose: To compare the safety and efficacy of two treatment …
January 23rd, 2006, by David Pascoe | doxycycline, ocular rosacea
Another paper confirming the importance of MMP and the inflammation found in ocular and facial rosacea. This follows up on another recent article suggesting that a diagnostic test for ocular rosacea could be based on the “high abundance of oligosaccharides in the tear fluid of patients with ocular rosacea”. MMPs have also been shown as important in the inflammatory pathway in other studies, see …
October 17th, 2005, by David Pascoe | doxycycline, ocular rosacea
Doxycycline is a broad spectrum antibiotic that chelates metal ions and is frequently used as part of treatment of ocular surface diseases. Its therapeutic value has been attributed to an ability to inhibit matrix metalloproteinase activity and both matrix metalloproteinase and interleukin-1 synthesis. Smith and Cook studied corneal epithelial cell and keratocyte cultures and in this study they demonstrated that the minimum concentration of doxycycline …
September 19th, 2005, by David Pascoe | doxycycline, oracea, tetracyclines
Some more background about subantimicrobial (sometimes referred to as SD – Subantimicrobial Dosage) doxycycline and rosacea. A dosage of around 50mg per day is enough to see a benefit in rosacea symptoms but also low enough to not affect gut flora or cause other antibiotic related side effects. SD doxycycline can also be take safely for longer periods of time compared to higher doses …
September 19th, 2005, by David Pascoe | doxycycline
Given the recent developments in periostat, oracea and COL-3 an interesting article about the applicability of low dose doxycycline. The term SDD refers to `subantimicrobial dose doxycycline hyclate’.
From US Pharmacist, Vol. No: 29:04 Posted: 4/15/04.
New Applications of Doxycycline Hyclate in Medicine and Dentistry
Golub and his colleagues were able to show that tetracycline exerted a unique property that was independent of its antimicrobial …
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