Rosacea Support Group » dermatitis

Sebclair launches as Promiseb Cream

David Pascoe — Tue, 11 Aug 2009 01:55:48 +0000

I was alerted to the launch of a product called Promiseb by a comment left on the Sebclair for Seborrheic Dermatitis post. Since then the news web sites are also covering the press release. Promiseb (probably pronounced Promi-seb) is launching in the U.S. via Promius Pharma, after being licensed from Sinclair Pharma in 2007.

Promiseb Topical Cream (Sebclair) is a non-steroidal, prescription only cream for the treatment of seborrheic dermatitis. It has demonstrated anti-inflammatory and anti-fungal properties. Sebclair is approved for use in the European Union to treat seborrheic dermatitis. One of Sebclair’s (and now Promiseb’s) claims to fame is that it contains no corticosteroids or immunomodulating agents.

Promiseb is claimed to “Significantly reduced Malassezia yeasts, the organisms that may cause seborrheic dermatitis, by 94%”. These claims are more interesting when you consider the ongoing discussions like Malassezia Globosa causes seborrhea, Pyrithione Zinc is effective, Could M. Globosa Cause Rosacea? and Real cause of seborrhea discovered!.

For a description of the ingredients and suggested method of action see Sebclair for seborrheic dermatitis.

From the press release: Sebclair launched in the US by Dr Reddy’s Laboratories’ subsidiary Promius Pharma, LLC

Jeff Wasserstein, President of Promius Pharma, said “We are very excited about Promiseb Cream because it has the potential to replace both anti-inflammatoryand antifungal treatments in patients with seborrheic dermatitis. In a clinicalstudy Promiseb was shown to have efficacy comparable to desonide cream 0.05% atdays 14 and 28 with fewer relapses.

“Promiseb Cream also has an excellent safety profile with no restrictions onage, duration of use or application on the face.” He continued, “We are very enthusiastic about this product because our clinical research shows thatPromiseb Cream may be used as a first-line treatment for seborrheic flares andfor long-term maintenance”

A supporting web site for Promiseb is online at http://promiseb.com/.

[update:] Auburn-NH has posted an early review of Promiseb, from using a doctor supplied sample.

rosacea allergic reaction to Vitamin K & Vitamin E

David Pascoe — Fri, 18 Jul 2008 03:15:49 +0000

This paper raises an interesting topic. The researchers were able to prove that 3 rosacea sufferers were allergic to alpha-tocopherol (Vitamin E) and Vitamin K. By eliminating the components of the creams they were using, they were able to isolate the individual components that were causing the allergy.

Rosacea sufferers can become attuned to the ingredient listing in cosmetics, scouring the list to find something that may irritate. It is worth knowing that even the so-called wonder ingredients themselves may be unsuitable for some. Vitamin E has been included in many products for many years and doesn’t seem to generally bother rosacea sufferers. Vitamin K is a more recent nutrient that became interesting to rosacea sufferers because of its positive affect on blood vessels.

Contact allergy from vitamins in cosmetic products, Dermatitis. 2008 May-Jun;19(3):154-6, Ramírez Santos A, Fernández-Redondo V, Pérez Pérez L, Concheiro Cao J, Toribio J.

We report three new cases of allergic contact dermatitis due to vitamins in cosmetic creams. The first patient was diagnosed with worsening rosacea but had allergic contact dermatitis from alpha-tocopherol in a moisturizing cream. The second and third cases presented as acute eyelid dermatitis due to vitamin K in eyelid lifter creams. Repeated open application testing and patch tests with the actual products and individual components of the creams were useful in establishing the diagnosis.

sea buckthorn oil and atopic dermatitis
Rosacea Support Community: Vitamin E
Sebclair for seborrheic dermatitis
exotic and expensive cosmetics, do they work ?
choosing a moisturizer

Malassezia Globosa causes seborrhea, Pyrithione Zinc is effective

David Pascoe — Mon, 11 Feb 2008 12:37:30 +0000

Interesting threads on the Rosacea Support Forum started by Artist. Apparently it is well known but it was a surprise to me that seborrheic dermatitis is not caused by Pityrosporum ovale, but in fact Malassezia Globosa. The second bit of information that was surprising to me was not only that ketoconazole is effective against M. Globosa, but so is Pyrithione Zinc (PTZ).

Some great links to heaps more information and the ongoing discussion here ;

Rosacea Support Forum: Real cause of seborrhea discovered!
Rosacea Support Forum: Seb Derm & Rosacea Studies?

sea buckthorn oil and atopic dermatitis

David Pascoe — Tue, 11 Jul 2006 08:28:00 +0000

Effect of dietary supplementation with sea buckthorn (Hippophae rhamnoides) seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis.

Journal of Nutritional Biochemistry, 2000 Jun;11(6):338-40. Baoru Yang, Kirsti O. Kalimo, Raija L. Tahvonen, Leena M. Mattila, Jouko K. Katajisto and Heikki P. Kallio.

Sea buckthorn (Hippophae rhamnoides) seed and pulp oils have traditionally been used for treating skin diseases in China and Russia, but are not widely used in other countries. A placebo-controlled, parallel study was carried out to investigate the effects of these oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis. Sixteen patients ate 5 g of sea buckthorn seed oil, pulp oil, or paraffin oil daily for 4 months. Skin fatty acids were analyzed with gas chromatography before and after treatment. The seed oil slightly increased the proportion of docosapentaenoic acid (22:5n-3) and decreased the proportion of palmitic acid (16:0) in skin glycerophospholipids (0.05 < P < 0.1). The levels of the other fatty acids remained stable. The results show that the fatty acid composition of skin glycerophospholipids is well buffered against short-term dietary modification.

Author Keywords: atopic dermatitis; Hippophaë rhamnoides; skin fatty acids; sea buckthorn oils

Seabuckthorn seed oil contains a high content of the two essential fatty acids, linoleic acid and α-linolenic acid (Chen et al. 1990), which are precursors of other polyunsaturated fatty acids such as arachidonic and eicosapentaenoic acids.The oil from the pulp/peel of seabuckthorn berries is rich in palmitoleic acid and oleic acid (Chen et al. 1990). In the present study, we tested the effects of dietary supplementation with the two oils on the fatty acid composition of plasma phospholipids, plasma neutral lipids and skin glycerophospholipids of atopic dermatitis patients.

Discussion The efficiency of incorporation and metabolism of dietary linoleic and α-linolenic acids strongly affects the essential fatty acid status of the human body.

In the present study, clear increases in the levels of α-linolenic acid and total n-3 fatty acids in plasma phospholipids and neutral lipids were already recognized after a one-month administration of seed oil.
…
The increase in the level of α-linolenic acid in plasma lipids showed a clear improving effect on atopic dermatitis symptoms (Yang et al. 1999a).
…
The high level of palmitoleic acid in pulp oil significantly increased the proportion of fatty acid in plasma lipids without a clear effect on the levels of polyunsaturated fatty acids or improvement of atopic dermatitis symptoms (Yang et al. 1999a).

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