Thanks to a comment from Sophie on the post rosacea and doxium (calcium dobesilate) we know that Dr. Cuevas who is responsible for several papers on Dobesilate, is accepting people to try it as a treatment for rosacea. Thanks for the info Sophie.
Calcium dobesilate (2,5-dihydroxybenzene sulfonate) is a vasoactive drug with presumed effects on endothelial integrity, capillary permeability and blood viscosity. It is often recommended for venous disorders, and also prescribed for diabetic retinopathy and other microvascular disorders.
rosacea and doxium (calcium dobesilate)
Just wanted to let others know that Dr. Cuevas accepted me as a participant in his clinical trial of the 2.5% Calcium dobesiliate cream. I had to arrange and pay for international shipping and managed to get the product into Canada (the product was described as a skin cream for customs purposes).
I have been using the skin cream for 2 weeks in the morning and evening. Redness has visibly decreased. My skin feels smooth and soft where there were small bumps previously. Spontaneous breakouts have also stopped. The study above was conducted over 4 weeks.
Anyone interested in participating in the clinical trial can submit photographs to Dr. Pedro Cuevas at:
pedro.cuevas@hrc.es
Dr. Pedro Cuevas
Servicio de Histología
Departamento de Investigación
Hospital Ramón y Cajal
Ctra. de Colmenar, km. 9.100
28034-Madrid-Spain
Tel. (0034) 913368290
Obviously rosacea sufferers have to be quite keen to pay for their own shipping, but it is only through research and trial and error that we will learn. Please do let us know if you too decide to try the calcium dobesilate cream.
This just published paper is suggesting that the topical application of polyphenol antioxidants (aka green tea) post IPL treatment resulted in more hydrated skin and reduced oxidative degradation of skin lipids. The authors suggest that this will enhance the effects of the IPL therapy.
This post-treatment therapy is in addition to some other recently published research that patients treated immediately after IPL with a LED device showed that their post-treatment redness subsided faster compared to not also being treated with LED.
We also know that 2% polyphenone in a hydrophilic cream has shown promise as a treatment for the papules and pustules of rosacea.
Topical polyphenolic antioxidants reduce the adverse effects of intense pulsed light therapy, J Cosmet Laser Ther. 2009 May 27:1-4, Freedman BM., Plastic Surgery Associates of Northern Virginia, McLean, Virginia, USA.
Background: Intense pulsed light therapy (IPL) has been associated with erythema and increased lipid peroxidation. Polyphenolic antioxidants have been shown to decrease inflammation and reduce oxidative stress in irradiated skin.
Objective: To determine whether the topical application of polyphenolic antioxidants to IPL-treated skin reduced the adverse effects of IPL exposure.
Methods: In a split-face study, 10 volunteers underwent three full-face IPL treatments (16 J/cm(2), 10ms, 560nm filter) spaced 3 weeks apart. A polyphenolic antioxidant solution was pneumatically applied to the left side of the face, beginning immediately before the first IPL treatment then weekly for six treatments. The lipid peroxide concentration, skin antioxidant level and skin moisture content were obtained before and after the study.
Results: Skin treated with IPL alone contained a significantly higher concentration of lipid peroxides when compared to skin treated with IPL plus polyphenolic antioxidants (p<0.05). Skin treated with IPL alone contained a significantly lower level of polyphenolic antioxidants and had a significantly lower moisture content (p<0.05).
Conclusions: In this study, the concurrent pneumatic topical application of polyphenolic antioxidants reduced lipid peroxidation and skin dehydration in IPL-treated skin. Polyphenolic antioxidants may confer a protective effect on facial skin and enhance the effects of IPL therapy.
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