Articles from February 2009 ↓
February 10th, 2009, by David Pascoe | seborrheic dermatitis, topicals
It looks like Australians can easily get this preparation via mail and pay via paypal.
It appears to be called Atopiclair and is available from
http://www.atopiclair.com.au/ It is listed as Atopiclair Cream 40ml and is $49 including postage to anywhere in Australia.
The web site claims a “new, non-steroidal cream that is designed to relieve the symptoms and signs of eczema (atopic dermatitis) and allergic dermatitis (contact dermatitis).”
Going by the papers they cite on that page and the paper above both quoting MAS063DP (Atopiclair[TM]), and the fact that Otco Global is listed as the Australian distributor – I’d say that this is Sebclair.
Sebclair (MAS064D) is approved for use in the European Union to treat seborrheic dermatitis. One of Sebclair’s claim to fame is that it contains no corticosteroids or immunomodulating agents. The paper’s authors admit that it is difficult to know which compound is responsible for Sebclair’s success as a treatment.
The authors state “We believe that the major activity is probably due to the synergistic effect of both piroctone olamine, for its antimycotic action, and glycyrrhetinic acid, for its anti-inflammatory action.”
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February 4th, 2009, by David Pascoe | galderma, in the news, topicals
The FDA has recently approved Vectical (topcial vitamin D3 from Galderma) for the treatment of plaque psoriasis. The active ingredient of Vectical is known as calcitrol and is a naturally occurring form of vitamin D3. Calcitrol has been shown safe to use for extended periods up to 52 weeks and also on sensitive skin fold areas. Users of Vectical should avoid exposure to the sun.
The mechanism of action of calcitrol in the treatment of psoriasis has not been established but Vitamin D3 has been shown to contribute "to the regulation of development and function of mast cells, which play a critical role in several inflammatory disorders”. Also it seems to have important immunomodulating effects, both reducing levels of pro-inflammatory cytokines and increasing levels of anti-inflammatory cytokines. See RSRP: Vitamin D3 for more information.
The Vectical prescribing information says that it should not be applied to the eyes, lips or facial skin. This may well limit the applicability of Vectical to treat rosacea of course. With all of the interest in Vitamin D3, this new product does look interesting though.
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It looks like Australians can easily get this preparation via mail and pay via paypal.
